Size matters: how sample size affects the reproducibility and specificity of gene set analysis
نویسندگان
چکیده
منابع مشابه
Gene Size Matters
In this work we show that in genome-wide association studies (GWAS) there is a strong bias favoring of genes covered by larger numbers of SNPs. Thus, we state here that there is a need for correction for such bias when performing downstream gene-level analysis, e.g. pathway analysis and gene-set analysis. We investigate several methods of obtaining gene level statistical significance in GWAS, a...
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ژورنال
عنوان ژورنال: Human Genomics
سال: 2019
ISSN: 1479-7364
DOI: 10.1186/s40246-019-0226-2